A 25-YEAR OBSERVATION OF A JAPANESE FEMALE PATIENT WITH Hb NOTTINGHAM WHO HAS TWO CHILDREN WITH THE SAME DISORDER

作者：Cho Yuko^*; Iizuka Susumu; Hatae Yoshio; Kobayashi Kunihiko; Hattori Yukio; Yamashiro Yasuhiro; Ariga Tadashi

来源：Hemoglobin, 2012, 36(5): 446-455.

DOI：10.3109/03630269.2012.703980

• Hb Nottingham
• Splenectomy
• Pregnancy
• Nucleated red blood cells (NRBCs)
• Neonatal course

We undertook a 25-year observation of a female patient with an unstable variant, Hb Nottingham or beta 98(FG5)Val -%26gt; Gly, GTG%26gt;GGG. The proband was diagnosed with Hb Nottingham at the age of 9 years. Splenectomy was performed in order to successfully aid her height growth due to chronic anemia at the age of 11, although anemia improvement was transient. She experienced pregnancy/delivery twice, at age 23 and 26, respectively. During both pregnancies, a large number of nucleated red blood cells (NRBCs) appeared in her peripheral blood. No developmental delay of the fetus was noted in either pregnancy, and she gave birth without any maternal complications or perinatal problems. Both babies were diagnosed with Hb Nottingham. To the best of our knowledge, this is the first report of a long-term observation of a proband with Hb Nottingham, including her pregnancy/delivery and the neonatal course of her children with the same disorder.

• 出版日期2012