Association study between the neurexin-1 gene and tardive dyskinesia

作者：Lanning Rachel; Lett Tristram A; Tiwari Arun K; Brandl Eva J; de Luca Vincenzo; Voineskos Aristotle N; Potkin Steven G; Lieberman Jeffrey A; Meltzer Herbert Y; Muller Daniel J; Remington Gary; Kennedy James L^*; Zai Clement C^*

来源：Human Psychopharmacology: Clinical and Experimental , 2017, 32(1): UNSP e2568.

DOI：10.1002/hup.2568

• antipsychotics
• neurexin-1 (NRXN1)
• pharmacogenetic
• schizophrenia (SCZ)
• tardive dyskinesia (TD)

ObjectiveTardive dyskinesia (TD) is a motor side effect that may develop after long-term antipsychotic treatment. Schizophrenia has recently been associated with the Neurexin-1 (NRXN1) gene that codes for a cell adhesion molecule in synaptic communication.
MethodsThis study examined five NRXN1 single-nucleotide polymorphisms (SNPs) for possible association with the occurrence and severity of TD in 178 schizophrenia patients of European ancestry.
ResultsWe did not find these SNPs to be significantly associated with TD.
ConclusionsMore research is needed with additional SNPs and in bigger samples before we can completely rule out the role of NRXN1 in TD.

• 出版日期2017-1
• 单位西北大学; 河北医科大学