DPPIV (CD26) as a novel stem cell marker in Ph plus chronic myeloid leukaemia

作者：Valent Peter^*; Sadovnik Irina; Racil Zdenek; Herrmann Harald; Blatt Katharina; Cerny Reiterer Sabine; Eisenwort Gregor; Lion Thomas; Holyoake Tessa; Mayer Jiri

来源：European Journal of Clinical Investigation, 2014, 44(12): 1239-1245.

DOI：10.1111/eci.12368

• Diagnostics
• leukaemia
• leukaemic stem cells
• stem cell
• phenotyping

The concept of leukaemic stem cells (LSCs) has been developed to explain the complex cellular hierarchy and biology of leukaemias and to screen for pivotal targets that can be employed to improve drug therapies through LSC eradication in these patients. Some of the newly discovered LSC markers seem to be expressed in a disease-specific manner and may thus serve as major research tools and diagnostic parameters. A useful LSC marker in chronic myeloid leukaemia (CML) appears to be CD26, also known as dipeptidylpeptidase IV. Expression of CD26 is largely restricted to CD34(+)/CD38(-) LSCs in BCR/ABL1(+) CML, but is not found on LSCs in other myeloid or lymphoid neoplasms, with the exception of lymphoid blast crisis of CML, BCR/ABL1(p210)+ acute lymphoblastic leukaemia, and a very few cases of acute myeloid leukaemia. Moreover, CD26 usually is not expressed on normal bone marrow (BM) stem cells. Functionally, CD26 is a cytokine-targeting surface enzyme that may facilitate the mobilization of LSCs from the BM niche. In this article, we review our current knowledge about the biology and function of CD26 on CML LSCs and discuss the diagnostic potential of this new LSC marker in clinical haematology.

• 出版日期2014-12
• 单位煤炭科学技术研究院有限公司