Anticonvulsant effect of A(1) but not A(2A) adenosine receptors of piriform cortex in amygdala-kindled rats

作者：Rezvani Mohammad Ebrahim; Mirnajafi Zadeh Javad^*; Fathollahi Yaghoub; Palizvan Mohammad Reza

来源：Canadian Journal of Physiology and Pharmacology, 2007, 85(6): 606-612.

DOI：10.1139/Y07-046

• seizure
• adenosine receptors
• piriform cortex
• amygdala
• kindling

In this study, the effect of At and A(2A) adenosine receptor activity of the piriform cortex (PC) on amyadala-kindled seizures was investigated in rats. Animals were kindled by daily electrical stimulation of the amygdala. In fully kindled rats, N-6-cyclohexyladenosine (CHA, a selective A(1) agonist), 8-cyclopentyl-1,3-dimethylxanthine (CPT, a selective At antagonist), CGS21680 hydrochloride (CGS, a selective A2A agonist), and ZM241385 (ZM, a selective A(2A) antagonist) were microinjected bilaterally into the PC. Rats were stimulated 5 min post-drug microinjection and seizure parameters were measured. Results showed that intra-PC CHA (10 and 100 mu mol/L) decreased the duration of both afterdischarge and stage 5 seizure and significantly increased the latency to stage 4 seizure. Intra-PC CPT increased afterdischarge and stage 5 seizure duration at the dose of 20 mu mol/L. The anticonvulsant effect of CHA (100 mu mol/L) was eliminated by CPT (10 mu mol/L) pretreatment. On the other hand, neither intra-PC CGS nor ZM had a significant effect on kindled seizures. These results suggest that activity of A(1), but not A(2A), receptors of the PC have anticonvulsant effects on kindled seizures elicited from electrical stimulation of the amygdala.

• 出版日期2007-6