Multifunctional core-shell nanoplatforms (gold@graphene oxide) with mediated MR thermal therapy to promote miRNA delivery

作者：Assali Akram; Akhavan Omid; Adeli Mohsen; Razzazan Shayan; Dinarvand Rassoul; Zanganeh Saeid; Soleimani Masoud; Dinarvand Meshkat; Atyabi Fatemeh^*

来源：Nanomedicine: Nanotechnology, Biology and Medicine , 2018, 14(6): 1891-1903.

DOI：10.1016/j.nano.2018.05.016

• Gold nanoplatfonn
• Graphene oxide
• miRNA
• Photothennal therapy
• Poly-L-arginine

Recent insights into the nanomedicine have revealed that nanoplatforms enhance the efficacy of carrier in therapeutic applications. Here, multifunctional nanoplatforms were utilized in miRNA-101 delivery and NIR thermal therapy to induce apoptosis in breast cancer cells. Au nanorods (NRs) or nanospheres (NSs) covered with graphene oxide (GO) were prepared and functionalized with polyethylene glycol as a stabilizer and poly-L-arginine (P-L-Arg) as a targeting agent. In nanoplatforms, coupling Au@GO prepared stable structures with higher NIR reactivity. P-LArg substantially enhanced the cellular uptake and gene retardation of stuffs coated by them. However, rod-shape nanoplatforms indicated better performance in cellular uptake and gene transfection than spherical ones. NIR thermal therapy was implemented to improve gene release and in synergy with miRNA-101 activated the apoptotic pathway and decreased the viability of breast cancer cell (<20%). Briefly, presented delivery systems are potentially efficient in distinguishing cancer cells, miRNA internalization and controlling apoptosis of cancer cells.

• 出版日期2018-8