A novel cancer imaging method using chemiluminescence-mediated sonosensitization

作者：He, YH; Xing, D^*; Wang, J

来源：Chinese Science Bulletin, 2003, 48(8): 777-780.

DOI：10.1360/02wc0368

• cancer diagnosis
• sonodynamic
• chemiluminescence

In this paper, we introduce a novel method named chemiluminescence mediated sono dynamic diagnosis (SDD), which is designed as follows: sonosensitizer is used to localize the cancer tissue, and is sonosensitized by the ultrasound field to produce oxygen free radicals. Then, another agent, FCLA (fluoresceinyl cypridina luciferin analog), reacts with O-1(2) to efficiently transform the chemical energy of O-1(2) to photons, thus a strong chemiluminescence is emitted. One can then detect this emission with a high sensitive CCD imaging system to localize the tumor. Based on the principle of chemiluminescence mediated SDD, we obtained a clear diagnostic image of a transplanted tumor in a nude mouse in the experiments. This method could have potential applications in clinics for early stage tumor diagnosis.

• 出版日期2003-4
• 单位华南师范大学