Acetoacetanilides as Masked Isocyanates: Facile and Efficient Synthesis of Unsymmetrically Substituted Ureas

作者：Wei, Ying; Liu, Jing; Lin, Shaoxia; Ding, Hongqian; Liang, Fushun^*; Zhao, Baozhong

来源：Organic Letters, 2010, 12(19): 4220-4223.

DOI：10.1021/ol101474f

• C-H ACTIVATION
• DOMINO REACTION
• AMINES
• DERIVATIVES
• INHIBITORS
• ARYLATION
• STRATEGY
• CATALYST
• CO2

A general and practical method for the preparation of unsymmetrically substituted ureas has been developed. By the reactions of acetoacetanilides with various amines including primary/secondary amines, a series of substituted aryl ureas were achieved in high yields. Acetoacetanilide substrates can be considered as masked reagents that liberate reactive isocyanates in situ.

• 出版日期2010-10-1
• 单位东北师范大学