An efficient, three-component synthesis of isoindolin-1-one-3-phosphonates under mild and solvent-free conditions

作者：Adib Mehdi^*; Sheikhi Ehsan^*; Yazzaf Rozita; Bijanzadeh Hamid Reza; Mirzaei Peiman

来源：Tetrahedron Letters, 2016, 57(8): 841-844.

DOI：10.1016/j.tetlet.2015.12.055

• Multi-component reactions
• Isoindolin-l-one-3-phosphonates
• 2-Formylbenzoic acids
• Primary amines
• Trialkyl phosphites
• Solvent-free synthesis

An efficient and mild three-component synthesis of isoindolin-1-one-3-phosphonates is described. The reaction between a 2-formylbenzoic acid, a primary amine, and a trialkyl phosphite proceeded at ambient temperature under catalyst-and solvent-free conditions to afford the desired compounds in excellent yields.

• 出版日期2016-2-24