A comprehensive guide to the ROMK potassium channel: form and function in health and disease

作者：Welling Paul A^*; Ho Kevin

来源：American Journal of Physiology - Renal Fluid and Electrolyte Physiology, 2009, 297(4): F849-F863.

DOI：10.1152/ajprenal.00181.2009

• K(ir)1.1
• KCNJ
• inward-rectifying potassium channel
• Bartter's syndrome
• pseudohypoaldosteronism type II
• serine- and glucocorticoid-regulated kinase-1
• WNK kinase
• phosphatidylinositol 4,5-bisphosphate

Welling PA, Ho K. A comprehensive guide to the ROMK potassium channel: form and function in health and disease. Am J Physiol Renal Physiol 297: F849-F863, 2009. First published May 20, 2009; doi:10.1152/ajprenal.00181.2009.-The discovery of the renal outer medullary K(+) channel (ROMK, K(ir)1.1), the founding member of the inward-rectifying K(+) channel (K(ir)) family, by Ho and Hebert in 1993 revolutionized our understanding of potassium channel biology and renal potassium handling. Because of the central role that ROMK plays in the regulation of salt and potassium homeostasis, considerable efforts have been invested in understanding the underlying molecular mechanisms. Here we provide a comprehensive guide to ROMK, spanning from the physiology in the kidney to the organization and regulation by intracellular factors to the structural basis of its function at the atomic level.

• 出版日期2009-10