Decreased percentage of memory B cells is independently associated with increased susceptibility to infection in patients on maintenance hemodialysis

作者：Guo, Man; Chen, Rongyi; Xiang, Fangfang; Cao, Xuesen; Hu, Jiachang; Lu, Zhihui; Gong, Shaomin; Chen, Xiaohong; Chen, Xiao; Ding, Xiaoqiang; Shen, Bo^*; Zou, Jianzhou^*

来源：International Urology and Nephrology, 2018, 50(11): 2081-2090.

DOI：10.1007/s11255-018-1977-8

• B cell subsets
• Memory B cells
• Immunoglobulin
• Hemodialysis
• Infection

PurposeInfection is a common complication and cause of death in patients on maintenance hemodialysis (MHD). B lymphocytes, which are an important component of the immune system, play a significant role in defending against pathogen invasion. However, in patients on MHD, the connection between infection and B cell subsets remains largely unknown. Our study aims to clarify the potential role of the distribution of B cell subsets in the infection process in patients on MHD.MethodsIn this cross-sectional study, basic information was collected from 175 patients on MHD from July 2016 to July 2017at Zhongshan Hospital, Fudan University. The distributions of the B cell subsets in patients with and without infection were analyzed using flow cytometry to determine the role of B lymphocyte subsets in the infection process in patients on MHD.ResultsAmong the 175 patients, 45 suffered from infection. The respiratory tract was the most common infection site, accounting for 67.86% of all infections. After adjustment using multivariate logistic regression models, memory B cells [per 1% increase, odds ratio [95% confidence interval (CI)]: 0.949 (0.915, 0.984), P<0.01], switched memory B cells [per 1% increase, odds ratio (95% CI): 0.939 (0.898, 0.982), P<0.01], naive B cells [per 1% increase, odds ratio (95% CI): 1.042 (1.009, 1.075), P<0.05] and IgG titers [per 1g/L increase, odds ratio (95% CI): 0.779 (0.630, 0.963), P<0.05] were independent risk factors for infection in dialysis patients.ConclusionA decrease in memory B cells is independently associated with an increased risk of infection in patients on dialysis.

• 出版日期2018-11
• 单位复旦大学