Mitochondria, calcium and cell death: A deadly triad in neurodegeneration

作者：Celsi Fulvio; Pizzo Paola; Brini Marisa; Leo Sara; Fotino Carmen; Pinton Paolo; Rizzuto Rosario^*

来源：Biochimica et Biophysica Acta-Bioenergetics, 2009, 1787(5): 335-344.

DOI：10.1016/j.bbabio.2009.02.021

• Mitochondria
• Calcium
• Neurodegenerative disease
• Alzheimer's disease
• Parkinson's disease
• Huntington's disease

Mitochondrial Ca2 accumulation is a tightly controlled process, in turn regulating functions as diverse as aerobic metabolism and induction of cell death. The link between Ca2 (dys) regulation, mitochondria and cellular derangement is particularly evident in neurodegenerative disorders, in which genetic models and environmental factors allowed to identify common traits in the pathogenic routes. We will here summarize: i) the current view of mechanisms and functions of mitochondrial Ca2 homeostasis, ii) the basic principles of organelle Ca2 transport, iii) the role of Ca2 in neuronal cell death, and iv) the new information on the pathogenesis of Alzheimer's, Huntington's and Parkinson's diseases, highlighting the role of Ca2 and mitochondria.

• 出版日期2009-5