Minimally invasive procedures for intracerebral hematoma evacuation in early stages decrease perihematomal glutamate level and improve neurological function in a rabbit model of ICH

作者：Wu Guofeng^*; Wang Likun; Wang Fan; Feng Anrong; Sheng Fei

来源：Brain Research, 2013, 1492: 140-147.

DOI：10.1016/j.brainres.2012.11.023

• Cerebral hemorrhage
• Minimally invasive procedure
• Glutamate
• Blood brain barrier
• Neurological deficit score

Introduction: To observe the effects of performing a minimally invasive procedure at different stages after intracerebral hemorrhage (ICH) on perihematomal glutamate level and neurological function. Methods: Forty-eight rabbits were randomly placed into a model control group (MC group, 24 rabbits) or a minimally invasive group (MI group, 24 rabbits). An ICH model was established in all of the animals. In the MI group, the ICH was evacuated by minimally invasive procedures in 6 h (6 rabbits), 12 h (6 rabbits), 18 h (6 rabbits) and 24 h (6 rabbits) after the ICH model was successfully induced. All of the animals were sacrificed within 48 h after the hematoma was evacuated by surgery. A neurological deficit score was determined, and the perihematomal glutamate level and the BBB permeability were measured. Results: The neurological deficit score, perihematomal glutamate level and BBB permeability of the MI group were decreased significantly compared with the MC group. Performing the minimally invasive procedures in 6-12 h after ICH showed the most significant decreases of the glutamate level, BBB permeability and neurological deficit score. Conclusions: The optimal time window of performing the minimally invasive procedures for the intracerebral hematoma evacuation might be within 6-12 h after hemorrhage.

• 出版日期2013-1-25
• 单位贵州医科大学