科研之友
微信
新浪微博
Facebook
分享链接
摘要
The word 'matrikine' designates certain peptides derived from partial degradation of extracellular matrix macromolecules and capable of modulating cellular activities. Some matrikines have been shown to inhibit tumor progression and/or neo-angiogenesis, suggesting they may have therapeutic potential. This review examines the main matrikines with anti-tumoral properties, and particularly those originating from basement membrane macromolecules. After a brief description of their discovery and main characteristics, we discuss their mode of production, mechanism of anti-tumor action, and therapeutic potential.
- 出版日期2010-3
