Allergic contact dermatitis and atopy

作者：Niebuhr M^*; Kapp A; Werfel T; Heratizadeh A

来源：Hautarzt, 2011, 62(10): 744-750.

DOI：10.1007/s00105-011-2182-1

• Atopic dermatitis
• Sensitization
• Patch tests
• Allergens
• Atopy

Retrospective studies demonstrate that the prevalence of skin sensitization does not significantly differ between atopic and nonatopic patients. In children and adolescents the risk for sensitization seems to occur independently from AD. According to the results of a recent study, AD patients are overrepresented in the group of polysensitized patients. IgE-mediated sensitization as well as an early onset of AD and duration of the disease have been identified as possible risk factors for skin sensitization to contact allergens. A defective permeability barrier with increased epidermal water loss is a hallmark of AD and contributes to sensitization against common allergens. A highly significant association between FLG mutations and the risk of early onset, severe, persistent AD and an increased risk for asthma has been shown in several studies. A more recent study revealed an association between FLG mutations and increased nickel sensitization, but not other contact allergens. However, further large prospective studies with well-characterized patients are necessary to clarify the correlation between impaired skin barrier, atopic dermatitis and allergic contact dermatitis.

• 出版日期2011-10