Iterative Synthesis of 1,3,5-Polyphenylene Dendrons via C-H Activation

作者：Finke Aaron D; Moore Jeffrey S^*

来源：Organic Letters, 2008, 10(21): 4851-4854.

DOI：10.1021/ol8019605

An iterative synthesis of 1,3,5-polyphenylene dendrons via C-H activation/Suzuki-Miyaura coupling up to a third generation dendron is described. C-H bonds at the focal points of the dendrons are selectively borylated via iridium-catalyzed borylation, eliminating the need for reactive protecting groups, Sequential additions of low catalyst loadings efficiently borylate higher-generation dendrons, whereas higher initial catalyst loadings are less efficient.

• 出版日期2008-11-6