N-(tert)-Butyloxycarbonyl-beta,beta-Cyclopentyl-Cysteine (Acetamidomethyl)-Methyl Ester for Synthesis of Novel Peptidomimetic Derivatives

作者：Mollica Adriano^*; Feliciani Federica; Stefanucci Azzurra; Cacciatore Ivana; Cornacchia Catia; Torino Domenica; Pinnen Francesco

来源：Protein and Peptide Letters, 2010, 17(7): 925-929.

• Peptides
• peptidomimetic
• cysteine
• thiols
• beta,beta-dialkyl-amino acids
• chi-space

It has been recently reported that thiol groups could play an important role in the protection of neuronal cells in Alzheimer's disease (AD), prion disease (CJD) and Parkinson's disease (PD). Also bucillamine, that is a pseudo dipeptide possessing a thiol group capable to form an internal disulfide bridge, has relevant scavenger properties used in therapy for the treatment of arthritis. Furthermore, many sulphur containing compounds show strong chelating properties to heavy metals. Due to the crucial role of thiol groups in a variety of detoxicant biological systems, we report the synthesis of a racemic, beta,beta-dialkyl-substituted, fully protected, cysteine derivative as a suitable intermediate in the synthesis of novel biological active peptides.

• 出版日期2010-7