Aberrant Changes of Wnt2/beta-Catenin Signaling Pathway Induced by Sodium Nitroprusside in Human Esophageal Squamous Cell Carcinoma Cell Lines

作者：Wang Wei; Xue Lexun^*; Liu Hongtao; Wang Pengju; Xu Peirong; Cai Yurong

来源：Cancer Investigation, 2010, 28(3): 230-241.

DOI：10.3109/07357900903095698

• Wnt2/beta-catenin
• Sodium nitroprusside
• siRNA
• Apoptosis
• Esophageal squamous cell carcinoma

Inhibition of Wnt/beta-catenin pathway is an attractive method for therapy of various tumors including breast, colorectal, and cervical cancer, etc. However, little is known about the role of Wnt2/beta-catenin pathway in esophageal squamous cell carcinoma (ESCC). Here we identify that Wnt2/beta-catenin signaling pathway is activated in ESCC cells, and sodium nitroprusside (SNP) and siRNA against beta-catenin not only inhibit the expressions of beta-catenin and its major downstream effectors including c-myc and cyclin D1, but induce cell cycle arrest and apoptosis, suggesting that Wnt2/beta-catenin pathway may be a potential molecular target for ESCC therapy.

• 出版日期2010-3
• 单位郑州大学