AN EFFICIENT SYNTHESIS OF 2,4 '-BI-1,3-OXA(THIA)ZOLES AS SCAFFOLDS FOR BIOACTIVE PRODUCTS

作者：Pena S; Scarone L; Manta E; Serra G^*

来源：Chemistry of Heterocyclic Compounds, 2011, 47(6): 703-709.

• bi-1,3-azoles
• alpha-halo ketone
• beta-hydroxy amides
• Hantzsch reaction
• oxidative cyclodehydration

A rapid and efficient methodology to prepare 2,4'-bi-1,3-azoles as scaffolds for biologically active marine natural products is described. Hantzsch reaction and oxidative cyclodehydration of beta-hydroxy amides or thioamides were used to construct the azole rings. The obtained biheterocycles displayed no cytotoxicity on HCT-15 cell line.

• 出版日期2011-9