Antileishmanial activity of aldonamides and N-acyl-diamine derivatives

作者：Coimbra Elaine S; Almeida Camila G; Junior Wilson V; Dos Reis Roberta C N; De Almeida Ana C F; Forezi Luana S M; De Almeida Mauro V; Le Hyaric Mireille^*

来源：The Scientific World Journal, 2008, 8: 752-756.

DOI：10.1100/tsw.2008.100

• N-acyl diamine
• aldonamide
• Leishmania

A number of lipophilic N-acyl-diamines and aldonamides have been synthesized and tested for their in vitro antiproliferative activity against Leishmania amazonensis and L. chagasi. Ribonamides, having one amino group, displayed good to moderate inhibition of parasite growth. The best result was obtained for compounds 10 and 15 with IC50 against L. chagasi below 5 microM.

• 出版日期2008