Association between HLA-B*1502 allele and carbamazepine-induced severe cutaneous adverse reactions in Han people of southern China mainland

作者：Wang, Qian; Zhou, Jue-qian^*; Zhou, Lie-min; Chen, Zi-yi; Fang, Zi-yan; Chen, Shu-da; Yang, Li-bai; Cai, Xiao-dong; Dai, Qi-lin; Hong, Hua; Wang, Hong-xuan

来源：Seizure-European Journal of Epilepsy, 2011, 20(6): 446-448.

DOI：10.1016/j.seizure.2011.02.003

• HLA-B*1502
• Carbamazepine
• Stevens-Johnson syndrome
• Toxic epidermal necrolysis
• Maculopapular eruption

Previous studies have found a strong association between HLA-B*1502 and carbamazepine-induced Stevens-Johnson syndrome in Asian areas including Taiwan, Hongkong and Thailand. This study explores the association between HLA-B*1502 allele and carbamazepine-induced cutaneous adverse reactions in Han Chinese of southern China mainland, and find the genetic marker that can predict carbamazepine-induced cutaneous adverse reactions. @@@ HLA-B*1502 allele genotyping was performed by a polymerase chain reaction-sequence specific primers (PCR-SSP) method in 48 Han Chinese subjects who had carbamazepine-induced cutaneous adverse reactions, including 9 severe cutaneous adverse reaction patients with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) and 39 cutaneous adverse reaction patients with maculopapular eruption (MPE). Meanwhile 80 carbamazepine-tolerant controls and 62 healthy individuals were also tested. @@@ The frequency of HLA-B*1502 allele among SJS/TEN patients (100%) is significantly higher than carbamazepine-tolerant controls (13.75%, P < 0.001) and healthy individuals (17.74%, P < 0.001). But the frequency between MPE patients and carbamazepine-tolerant controls (25.64% vs.13.75%, P = 0.110) did not have any significant difference. @@@ The data showed that HLA-B*1502 allele is strongly associated with carbamazepine-induced SJS/TEN but not MPE in Han Chinese of southern China mainland.

• 出版日期2011-7
• 单位中山大学