Morphological weighted penalized least squares for background correction

作者：Li, Zhong; Zhan, De-Jian; Wang, Jia-Jun; Huang, Jing; Xu, Qing-Song^*; Zhang, Zhi-Min; Zheng, Yi-Bao; Liang, Yi-Zeng; Wang, Hong

来源：Analyst, 2013, 138(16): 4483-4492.

DOI：10.1039/c3an00743j

• BASE-LINE CORRECTION
• HIGHLY FLUORESCENT SAMPLES
• LIQUID-CHROMATOGRAPHY
• RAMAN-SPECTRA
• WAVELET TRANSFORM
• SPECTROSCOPY
• SUBTRACTION
• REMOVAL
• QUANTIFICATION
• CLASSIFICATION

Backgrounds existing in the analytical signal always impair the effectiveness of signals and compromise selectivity and sensitivity of analytical methods. In order to perform further qualitative or quantitative analysis, the background should be corrected with a reasonable method. For this purpose, a new automatic method for background correction, which is based on morphological operations and weighted penalized least squares (MPLS), has been developed in this paper. It requires neither prior knowledge about the background nor an iteration procedure or manual selection of a suitable local minimum value. The method has been successfully applied to simulated datasets as well as experimental datasets from different instruments. The results show that the method is quite flexible and could handle different kinds of backgrounds. The proposed MPLS method is implemented and available as an open source package at http://code.google.com/p/mpls.

• 出版日期2013
• 单位中南大学; 云南省烟草农业科学研究院