科研之友
微信
新浪微博
Facebook
分享链接
摘要
AIM To compare the therapeutic effect of the herbal medicine Zhishi Xiaopiwan with that of Cisapride in the treatment of functional dyspepsia (FD). METHODS Fifty-one FD patients were randomized into Herbal group (n = 27) and Cisapride group (n = 24). Two groups were given a four-week treatment of Zhishi Xiaopiwan 100 mi, tid, a. c. and Cisapride 5 mg, tid, a. c. respectively. Patients' symptoms were assessed and 39 patients' (22 of Herbal group and 17 of Cisapride group) gastric liquid emptying times were measured with ultrasonography before and after the treatment. RESULTS The therapeutic effective rates of Herbal group and Cisapride group were 81.49% and 87.50% (P>0.05). The half gastric emptying time (GET(50)) and gastric emptying time (GET) of healthy controls and FD patients were 36.12min +/- 10.22min vs 52.95min +/- 13.49min and 87.07min +/- 21.11min vs 120.74min +/- 23.08min (P < 0.001). The GET(50) and GET of Herbal group before and after the treatment were 51.63min +/- 13.15min vs 45.62min +/- 10.82min and 117.34min +/- 23.29min vs 103.26min +/- 22.19min (P < 0.01). The results of Cisapride group were 54.66min +/- 14.14min vs 40.95min +/- 11.29min and 125.12min +/- 24.47min vs 95.49min +/- 22.31min (P < 0.01). The differences in values (median) of GET(50) and GET for Herbal group and Cisapride group before and after treatment were 5.75min vs 17.18min and 13.22min vs 33.54min (P<0.05). CONCLUSION Delayed gastric emptying is one of the pathogenesis of FD. Both Zhishi Xiaopi pills and Cisapride can effectively alleviate the symptoms of FD and accelerate gastric liquid emptying. The effect of Zhishi Xiaopiwan on enhancing gastric motility is comparable with but less than that of Cisapride.
- 出版日期1998-12
- 单位上海市闵行区中心医院; 上海中医药大学
