Asymmetric Michael addition of aldehydes to nitroolefins catalyzed by a pyrrolidine-pyrazole

作者:Kumar Togapur Pavan*
来源:Tetrahedron: Asymmetry , 2014, 25(18-19): 1286-1291.
DOI:10.1016/j.tetasy.2014.07.005

摘要

An effective protocol for the stereoselective Michael addition of aldehydes to nitroolefins using pyrrolidine-pyrazole as an organocatalyst is described. The catalytic cycle was found to be productive in terms of yield and selectivity, when performed under solvent-free reaction conditions and employing 15 mol % of catalyst and 10 mol % of benzoic acid at room temperature.

  • 出版日期2014-10-15