Physicochemical properties and antidiabetic effects of a polysaccharide obtained from Polygonatum odoratum

作者：Jiang, Huiyan; Xu, Yao; Sun, Congyong; Adu-Frimpong, Michael; Yu, Jiangnan^*; Deng, Wenwen^*; Xu, Ximing^*

来源：International Journal of Food Science and Technology, 2018, 53(12): 2810-2822.

DOI：10.1111/ijfs.13896

• Polygonatum odoratum
• polysaccharides
• structure
• type 2 diabetes mellitus mice

In this study, we isolated a novel polysaccharide (YZ-2) (molecular weight: 5345.3 Da) from Polygonatum odoratum (Mill.) Druce and investigated its physicochemical properties and antidiabetic effects in the type 2 diabetic mellitus (T2DM) mice induced by a low dose of streptozotocin coupled with a high-fat diet. The results showed that YZ-2 had no triple-helix conformation and was mainly composed of alpha-mannopyranose, alpha-glucopyranose and alpha-galactopyranose residues. Moreover, YZ-2 could significantly decrease the fasting blood glucose (Glc) level (P < 0.01), the serum TC, TG and LDL-c concentrations (P < 0.05), as well as the fasting insulin level and improve the Glc tolerance capacity in the T2DM mice. Additionally, YZ-2 could protect livers and pancreas by remarkably increasing SOD and CAT activities and GSH content (P < 0.05) in the liver of T2DM mice. Collectively, these results suggested that YZ-2 could be a promising functional food supplement for T2DM treatment.

• 出版日期2018-12
• 单位江苏大学