Divergent asymmetric synthesis of hexahydrobenzophenanthridine dopamine D1 agonists, A-86929, and dihydrexidine

作者：Malhotra Rajesh; Chakrabarti Sagar; Ghosh Amit; Ghosh Rajib; Dey Tushar K; Dutta Swarup; Dutta Shantanu; Roy Subho; Basu Sourav^*; Hajra Saumen

来源：Tetrahedron: Asymmetry , 2013, 24(5-6): 278-284.

DOI：10.1016/j.tetasy.2013.02.003

A divergent and scalable asymmetric synthesis of the dopamine D1 agonists, A-86929, and dihydrexidine with high diastereo- and enantioselectivity was accomplished from Weinreb amide 8 derived from inexpensive and easily available L-serine. The synthesis of A-86929 involves only one chromatographic purification.

• 出版日期2013-3-31