Near-optimal experimental design for model selection in systems biology

作者：Busetto Alberto Giovanni^*; Hauser Alain; Krummenacher Gabriel; Sunnaker Mikael; Dimopoulos Sotiris; Ong Cheng Soon; Stelling Joerg; Buhmann Joachim M

来源：Bioinformatics, 2013, 29(20): 2625-2632.

DOI：10.1093/bioinformatics/btt436

Motivation: Biological systems are understood through iterations of modeling and experimentation. Not all experiments, however, are equally valuable for predictive modeling. This study introduces an efficient method for experimental design aimed at selecting dynamical models from data. Motivated by biological applications, the method enables the design of crucial experiments: it determines a highly informative selection of measurement readouts and time points.
Results: We demonstrate formal guarantees of design efficiency on the basis of previous results. By reducing our task to the setting of graphical models, we prove that the method finds a near-optimal design selection with a polynomial number of evaluations. Moreover, the method exhibits the best polynomial-complexity constant approximation factor, unless P = NP. We measure the performance of the method in comparison with established alternatives, such as ensemble non-centrality, on example models of different complexity. Efficient design accelerates the loop between modeling and experimentation: it enables the inference of complex mechanisms, such as those controlling central metabolic operation.

• 出版日期2013-10-15