Acquisition of Flucytosine, Azole, and Caspofungin Resistance in Candida glabrata Bloodstream Isolates Serially Obtained from a Hematopoietic Stem Cell Transplant Recipient

作者：Chapeland Leclerc Florence; Hennequin Christophe; Papon Nicolas; Noel Thierry; Girard Aurelie; Socie Gerard; Ribaud Patricia; Lacroix Claire^*

来源：Antimicrobial Agents and Chemotherapy, 2010, 54(3): 1360-1362.

DOI：10.1128/AAC.01138-09

We describe the acquisition of flucytosine, azole, and caspofungin resistance in sequential Candida glabrata bloodstream isolates collected from a bone marrow transplant patient with clinical failure. Point mutations in C. glabrata FUR1 (CgFUR1) and CgFKS2 and overexpression of CgCDR1 and CgCDR2 were observed in resistant isolates.

• 出版日期2010-3