An Efficient Synthesis of 3,3 %26apos;-Bipiperidines Using an ROM/RCM Metathesis Sequence: Extension to Oxygenated Analogues

作者：Maougal Esma; Dalencon Sylvain; Pearson Long Morwenna S M; Mathe Allainmat Monique; Lebreton Jacques^*; Legoupy Stephanie

来源：Synthesis (Germany), 2014, 46(23): 3268-3272.

DOI：10.1055/s-0034-1378663

• heterocyclics
• alkaloids
• metathesis
• piperidines
• cyclobutene

A short and efficient diastereoselective synthesis of 3,3-bipiperidine and 3,3-bis(1,2,3,6-tetrahydropyridine) was accomplished using a tandem ring-opening metathesis/ring-closing metathesis (ROM/RCM) sequence as a key step. This strategy has been extended to the synthesis of the oxygenated analogues.

• 出版日期2014-12