Promiscuous Candida antarctica lipase B-catalyzed synthesis of beta-amino esters via aza-Michael addition of amines to acrylates

作者：Dhake Kishor P; Tambade Pawan J; Singhal Rekha S; Bhanage Bhalchandra M^*

来源：Tetrahedron Letters, 2010, 51(33): 4455-4458.

DOI：10.1016/j.tetlet.2010.06.089

An efficient protocol for the regioselective aza-Michael addition of amines with acrylates using CaLB as a biocatalyst at 60 C has been developed The reaction is applicable to a wide variety of primary and secondary amines with different acrylates to synthesize the corresponding B-ammo esters with good yiel

• 出版日期2010-8-18