Adipocytes as a new source of catecholamine production

作者：Vargovic Peter^*; Ukropec Jozef; Laukova Marcela; Cleary Susannah; Manz Bernhard; Pacak Karel; Kvetnansky Richard

来源：FEBS Letters, 2011, 585(14): 2279-2284.

DOI：10.1016/j.febslet.2011.06.001

• Adipocyte
• Endogenous catecholamine
• Catecholamine biosynthetic enzyme
• Gene expression

Catecholamines are an important regulator of lipolysis in adipose tissue. Here we show that rat adipocytes, isolated from mesenteric adipose tissue, express genes of catecholamine biosynthetic enzymes and produce catecholamines de novo. Administration of tyrosine hydroxylase inhibitor, alpha-methyl-p-tyrosine, in vitro significantly reduced concentration of catecholamines in isolated adipocytes. We hypothesize that the sympathetic innervation of adipose tissues is not the only source of catecholamines, since adipocytes also have the capacity to produce both norepinephrine and epinephrine.

• 出版日期2011-7-21