Advanced glycation end products increase carbohydrate responsive element binding protein expression and promote cancer cell proliferation

作者：Chen, Hanbei; Wu, Lifang; Li, Yakui; Meng, Jian; Lin, Ning; Yang, Dianqiang; Zhu, Yemin; Li, Xiaoyong; Li, Minle; Xu, Ye; Wu, Yuchen; Tong, Xuemei^*; Su, Qing

来源：Molecular and Cellular Endocrinology, 2014, 395(1-2): 69-78.

DOI：10.1016/j.mce.2014.07.021

• Diabetes mellitus
• Cancer
• Advanced glycation end products
• Receptor for advanced glycation end-products
• Carbohydrate responsive element binding protein
• Proliferation

Diabetic patients have increased levels of advanced glycation end products (AGEs) and the role of AGEs in regulating cancer cell proliferation is unclear. Here, we found that treating colorectal and liver cancer cells with AGEs promoted cell proliferation. AGEs stimulated both the expression and activation of a key transcription factor called carbohydrate responsive element binding protein (ChREBP) which had been shown to promote glycolytic and anabolic activity as well as proliferation of colorectal and liver cancer cells. Using siRNAs or the antagonistic antibody for the receptor for advanced glycation end-products (RAGE) blocked AGEs-induced ChREBP expression or cell proliferation in cancer cells. Suppressing ChREBP expression severely impaired AGEs-induced cancer cell proliferation. Taken together, these results demonstrate that AGEs RAGE signaling enhances cancer cell proliferation in which AGEs-mediated ChREBP induction plays an important role. These findings may provide new explanation for increased cancer progression in diabetic patients.

• 出版日期2014-9-5
• 单位复旦大学; 上海交通大学; 大连医科大学