Uranium deposition in bones of Wistar rats associated with skeleton development

作者：Rodrigues G; Arruda Neto J D T^*; Pereira R M R; Kleeb S R; Geraldo L P; Primi M C; Takayama L; Rodrigues T E; Cavalcante G T; Genofre G C; Semmler R; Nogueira G P; Fontes E M

来源：Applied Radiation and Isotopes, 2013, 82: 105-110.

DOI：10.1016/j.apradiso.2013.07.033

• Uranium incorporation
• Wistar rats
• Skeleton bones
• Radiobiological effects
• Bone mineral density

Sixty female Wistar rats were submitted to a daily intake of ration doped with uranium from weaning to adulthood. Uranium in bone was quantified by the SSNTD (solid state nuclear track detection) technique, and bone mineral density (BMD) analysis performed. Uranium concentration as a function of age exhibited a sharp rise during the first week of the experiment and a drastic drop of 70% in the following weeks. Data interpretation indicates that uranium mimics calcium. Results from BMD suggest that radiation emitted by the incorporated Uranium could induce death of bone cells.

• 出版日期2013-12