Different miR-21-3p isoforms and their different features in colorectal cancer

作者：Jiao, Weijuan; Leng, Xueqin; Zhou, Qun; Wu, Yayun; Sun, Lina; Tan, Yan; Ni, Hengli; Dong, Xiaoqiang; Shen, Tong; Liu, Yao^*; Li, Jianming^*

来源：International Journal of Cancer, 2017, 141(10): 2103-2111.

DOI：10.1002/ijc.30902

• MiR-21-3p
• isoform
• colorectal cancer (CRC)
• epithelial-mesenchymal transition (EMT)

MiR-21, the only microRNA (miRNA) found to be overexpressed in any type of solid tumor, its guide stand, miR-21-5p, has been studied a lot in colorectal cancer (CRC); however, few researchers focused on its passenger strand, miR-21-3p. In our study, based on The Cancer Genome Atlas (TCGA) data, we found that there were more varieties and quantities of miR-21-3p isoforms in microsatellite instability (MSI)-type CRC. We further examined the role of miR-21-3p by in vitro and in vivo studies. MiR-21-3p may be an oncogene in CRC by promoting cellular mobility through epithelial-mesenchymal transition. However, different isoforms, especially miR-21-3p 0 vertical bar 2 may be a favorable prognostic marker for CRC survival, probably due to increased complementary effect of miR-21-5p and/or target genes. Further study investigating the underlying mechanism of miRNA isoforms is needed.

• 出版日期2017-11-15
• 单位苏州大学