Adiponectin administration alleviates DSS-induced colonic inflammation in Caco-2 cells and mice

作者：Zhao, Qin; Liu, Yang; Tan, Lei; Yan, Liyong; Zuo, Xiuli^*

来源：Inflammation Research, 2018, 67(8): 663-670.

DOI：10.1007/s00011-018-1155-6

• Adiponectin
• Inflammation
• Apoptosis
• Barrier

Adiponectin, a protein hormone produced by adipose tissues, exhibits anti-inflammatory functions in various models. This study was investigated the effects of adiponectin on dextran sodium sulfate (DSS)-colonic injury, inflammation, apoptosis, and intestinal barrier dysfunction in Caco-2 cell and mice.
The results showed that DSS caused inflammatory response and intestinal barrier dysfunction in vitro and in vivo. Adiponectin injection alleviated colonic injury and rectal bleeding in mice. Meanwhile, adiponectin downregulated colonic IL-1 beta and TNF-alpha expressions and regulated apoptosis relative genes to attenuate DSS-induced colonic inflammation and apoptosis. Adiponectin markedly reduced serum lipopolysaccharide concentration, a biomarker for intestinal integrity, and enhanced colonic expression of tight junctions (ZO-1 and occludin). The in vitro data further demonstrated that adiponectin alleviated DSS-induced proinflammatory cytokines production and the increased permeability in Caco-2 cells.
Adiponectin plays a beneficial role in DSS-induced inflammation via alleviating apoptosis and improving intestinal barrier integrity.

• 出版日期2018-8
• 单位泰安市中心医院; 山东大学