Adipocytokines Levels at Delivery, Functional Variation of TFAP2 beta, and Maternal and Neonatal Anthropometric Parameters

作者：Comasco Erika^*; Iliadis Stavros I; Larsson Anders; Olovsson Matts; Oreland Lars; Sundstrom Poromaa Inger; Skalkidou Alkistis

来源：Obesity, 2013, 21(10): 2130-2137.

DOI：10.1002/oby.20349

Objective: Adipocytokines participate in the regulation of glucose metabolism and fetal development. The transcription factor activating protein 2B (TFAP2 beta) has been associated with adipocytokine regulation, and gene variations with type 2 diabetes and obesity. This study investigated associations between maternal TFAP2B variation, adipocytokine levels, and maternal and neonatal anthropometric characteristics. %26lt;br%26gt;Design and Methods: A population-based sample of women was followed from delivery to 6 months postpartum. Adiponectin, leptin, and interleukin-6 levels at delivery, and maternal as well as neonatal anthropometric variables were assessed. The TFAP2 beta intron 1 variable number tandem repeat (VNTR) was genotyped. %26lt;br%26gt;Results: Maternal interleukin-6 correlated positively with leptin at delivery, with peripartum weight changes and weight of newborn males, adjusted for potential confounders. Leptin at delivery was associated with TFAP2 beta intron 1 VNTR genotype, adjusted for confounders, maternal weight and negatively with birth weight among female neonates. A path model suggested a link between TFAP2 beta genotype, leptin levels, and newborn females%26apos; weight. %26lt;br%26gt;Conclusions: The present results stress a role for the TFAP2 beta in adiposity-related conditions and intrauterine growth. The association between neonatal birth weight and maternal adipocytokine levels, together with the observed sex effect, call for further studies on the mechanisms behind neuroendocrine fetal programming.

• 出版日期2013-10