Artificial enzyme activity from cyclodextrins with cyanohydrins on the secondary rim

作者：Zhou You; Pedersen Christian M; Bols Mikael^*

来源：Tetrahedron Letters, 2013, 54(20): 2458-2461.

DOI：10.1016/j.tetlet.2013.02.091

• Chemzymes
• Glycosidase
• Cyclodextrin
• Catalysis
• General acid

The synthesis of two per-O-methylated cyclodextrins with one or two alpha-hydroxypropionitrile groups attached to the secondary rim is described. The two new cyanohydrins are found to catalyse the hydrolysis of 4-nitrophenyl beta-D-glucopyranoside in a buffer solution at pH 8.0 with a rate acceleration of up to 1770.

• 出版日期2013-5-15