Audiological monitoring in Swiss childhood cancer patients

作者：Weiss Annette; Kuonen Rahel; Brockmeier Hanna; Grotzer Michael; Candreia Claudia; Maire Raphael; Senn Pascal; Stieger Christof; Rosenfeld Jochen; Veraguth Dorothe; Kompis Martin; Scheinemann Katrin; Kuehni Claudia E.^*

来源：Pediatric Blood and Cancer, 2018, 65(3): e26877.

DOI：10.1002/pbc.26877

• childhood cancer

BackgroundFull audiological monitoring is the best strategy to detect hearing loss early and to provide timely intervention in the absence of a clinical method of otoprotection. Full monitoring requires audiological evaluation before, and then during and after ototoxic cancer treatment. In a worldwide context of monitoring protocols that vary substantially, we analyzed the audiological monitoring of childhood cancer patients over the last decade across treatment centers in Switzerland.
ProcedureWe retrospectively searched for audiological evaluations in all nine Swiss Pediatric Oncology Centers. We analyzed proportions of patients who had audiological monitoring and described type and timing of monitoring. We determined predictors of audiological monitoring using multivariable logistic regression and described time trends.
ResultsWe included 185 patients from the Swiss Childhood Cancer Registry diagnosed from 2005 to 2013 who had platinum chemotherapy and/or cranial radiation 30 Gray and who were alive at time of study. Less than half of children, 43%, had full audiological monitoring (before, during, and after treatment), while 72% were tested after cancer treatment. Nonstudy patients were less likely to have had monitoring in all phases of cancer treatment. Patients who received treatment with cisplatin or both platinum chemotherapy and cranial radiation were more likely to have had monitoring after treatment. Monitoring during and after treatment increased over the study period, but monitoring before treatment was insufficient in all time periods.
ConclusionsOur population-based study indicates that audiological monitoring is insufficient in Switzerland, particularly for nonstudy patients. Clinicians must become more aware of the importance of full audiological monitoring.

• 出版日期2018-3