Microwave-assisted selective and efficient synthesis of 1,3,5-triazinyl mono and bisureas

作者：Ruiz Carretero Amparo; Ramon Ramirez Jose; Sanchez Migallon Ana^*; de la Hoz Antonio

来源：Tetrahedron, 2014, 70(9): 1733-1739.

DOI：10.1016/j.tet.2014.01.043

• Microwave
• Triazine
• Green chemistry
• Ureas
• Hydrogen bonds

An efficient and sustainable microwave-assisted approach for the one-step preparation of a wide range of 1,3,5-triazinyl mono- and bisureas has been developed, combining solvent-free conditions and microwave irradiation. In these conditions the very unreactive amino groups of 1,3,5-triazine-2,4-diamines successfully react with phenylisocyanate to yield selectively mono and bisureas. %26lt;br%26gt;This protocol resulted in the shortest reaction times reported so far and is generally applicable for the preparation of these valuable heterocyclic systems.

• 出版日期2014-3-4