A new safety-catch protecting group and linker for solid-phase synthesis

作者：Thennarasu Sathiah; Liu Chuan Fa^*

来源：Tetrahedron Letters, 2010, 51(24): 3218-3220.

DOI：10.1016/j.tetlet.2010.04.047

The use of two derivatives of 2-methoxy-4-methylsulfinylbenzyl alcohol is demonstrated as a safety-catch protecting group and linker for solid-phase peptide synthesis. The protecting group and linker are stable to TFA and are readily removed under reductive acidolytic conditions.

• 出版日期2010-6-16
• 单位南阳理工学院