ASSOCIATION OF POLYCYSTIC OVARY SYNDROME AND A NON-DIPPING BLOOD PRESSURE PATTERN IN YOUNG WOMEN

作者：Kargili Ayse^*; Karakurt Feridun; Kasapoglu Benan; Derbent Aysel; Koca Cemile; Selcoki Yusuf

来源：Clinics, 2010, 65(5): 475-479.

DOI：10.1590/S1807-59322010000500004

• Polycystic ovary syndrome
• non-dipping blood pressure

OBJECTIVE: The association between polycystic ovarian syndrome and increased cardiovascular disease risk is still a controversial issue. In light of data documenting some common pathways or common end-points, the present study was undertaken to determine whether there is a relationship between sleep blood pressure pattern disturbances and polycystic ovarian syndrome in young women.
METHOD: The daytime and nighttime ambulatory blood pressures (BPs) were determined for each subject, according to the actual waking and sleeping times recorded in their individual diaries, in this cross-sectional study.
RESULTS: The study group comprised 168 women (mean age: 25.7 +/- 5.5) diagnosed with polycystic ovarian syndrome, while the control group included 52 age-and BMI-matched healthy subjects (mean age: 26.1 +/- 5.4). When nocturnal BP declines very little or not at all, with the BP falling less than 10% during sleep compared with waking values, this pattern is classified as a non-dipping BP pattern. However, the non-dipping pattern of BP changes was significantly more common in polycystic ovarian syndrome patients compared to the control group (p<0.01). The prevalence of a non-dipping BP pattern was 43.4% (73 patients) in polycystic ovarian syndrome patients and 3.9% (2 patients) in the control group.
CONCLUSION: Our cross-sectional study revealed that a non-dipping BP pattern is highly prevalent in polycystic ovarian syndrome patients, even if they are young and non-obese.

• 出版日期2010-5