Brainstem Auditory Evoked Potentials for diagnosing Autism Spectrum Disorder, ADHD and Schizophrenia Spectrum Disorders in adults. A blinded study

作者：Manouilenko Irina; Humble Mats B; Georgieva Jeanette; Bejerot Susanne^*

来源：Psychiatry Research, 2017, 257: 21-26.

DOI：10.1016/j.psychres.2017.06.085

• Mental disorder
• Double-blind method
• Auditory brainstem response

The aim of the present study was to examine the clinical utility of complex auditory brainstem response (c-ABR) and investigate if c-ABR is helpful in the diagnostic procedure. Thirty-one adult psychiatric patients, thoroughly diagnosed with autism spectrum disorder (ASD) (n=16), ADHD (n = 8), or schizophrenia spectrum disorder (SSD) (n = 7) and 15 healthy controls (HC), were blindly assessed with SensoDetect BERA. This c-ABR correctly identified psychiatric diagnoses in 4 patients (13%) and provided partially correct diagnoses in 11 more patients. Of the 15 HC, 6 were misclassified as psychiatric patients. The Cohen's kappa coefficient (kappa) was substantial for HC (kappa=0.67), fair for SSD (kappa = 0.37), slight for ADHD (kappa=0.09) and without agreement in ASD (kappa= -0.03). In conclusion, we found the c-ABR method unhelpful and unreliable as a tool in clinical diagnostics.

• 出版日期2017-11