A rapid hemostatic sponge based on large, mesoporous silica nanoparticles and N-alkylated chitosan

作者：Chen, Zihao; Han, Lei; Liu, Changjun; Du, Yu; Hu, Xiao; Du, Ge; Shan, Chao; Yang, Kun; Wang, Chunlai; Li, Minggao^*; Li, Fan^*; Tian, Feng^*

来源：Nanoscale, 2018, 10(43): 20234-20245.

DOI：10.1039/c8nr07865c

• EXTREMITY ARTERIAL HEMORRHAGE
• HEMOLYTIC-ACTIVITY
• MODEL
• DRESSINGS
• EFFICACY
• DELIVERY
• REPAIR
• AGENTS
• GAUZE

Rapid bleeding control is increasingly important in current civilian and military emergency medicine, but the rapid hemostasis achieved with current hemostatic products is often unsafe. In this study, mesoporous silica nanoparticles (MSNs) with large pores were coordinated with a glycerol-modified N-alkylated chitosan sponge (GACS) to develop a rapid and safe hemostatic sponge. Due to its coagulation-promoting structure, MSN-GACS exhibited unique hemostatic potency in serial in vitro coagulation tests. In addition to enhanced platelet adhesion and whole blood absorption, MSN-GACS exhibited better biocompatibility than Combat Gauze (CG), which is popular in the US military. Furthermore, in rabbit femoral artery and liver injury in vivo models, MSN-GACS showed better hemostatic efficiency and lower cardiovascular toxicity than CG. In conclusion, MSN-GACS is an excellent prehospital hemostatic agent for first-aid applications.

• 出版日期2018-11-21
• 单位中国人民武装警察部队学院; 首都医科大学; 中国人民解放军军事医学科学院; 河北医科大学; 中国人民解放军海军总医院; 河北大学