Novel Contrast-Enhanced Ultrasound Evaluation in Neonatal Hypoxic Ischemic Injury: Clinical Application and Future Directions

作者：Hwang Misun^*; De Jong Robert M Jr; Herman Stephan; Boss Renee; Riggs Becky; Tekes Brady Aylin; Spevak Melissa; Poretti Andrea; Soares Bruno P; Bailey Christopher R; Dunn Emily; Shin Samuel S; Shrot Shai; Huisman Thierry A G M

来源：Journal of Ultrasound in Medicine, 2017, 36(11): 2379-2386.

DOI：10.1002/jum.14289

• contrast-enhanced ultrasound
• hypoxic ischemic injury
• microbubbles
• neonates
• neuroimaging
• pediatric ultrasound

Sensitive, specific, and safe bedside evaluation of brain perfusion is key to the early diagnosis, treatment, and improved survival of neonates with hypoxic ischemic injury. Contrast-enhanced ultrasound (US) imaging is a novel imaging technique in which intravenously injected gas-filled microbubbles generate enhanced US echoes from an acoustic impedance mismatch. This article describes contrast-enhanced US imaging in 2 neonates with hypoxic ischemic injury and future directions on developing quantitative contrast-enhanced US techniques for improved characterization of perfusion abnormalities. The importance of studying the temporal evolution of brain perfusion in neonatal hypoxic ischemic injury is also highlighted.

• 出版日期2017-11