Microwave assisted synthesis of acrylamide grafted locust bean gum and its application in drug delivery

作者：Kaity Santanu; Isaac Jinu; Kumar P Mahesh; Bose Anirbandeep; Wong Tin Wui; Ghosh Animesh^*

来源：Carbohydrate Polymers, 2013, 98(1): 1083-1094.

DOI：10.1016/j.carbpol.2013.07.037

• Acrylamide grafted locust bean gum
• Biodegradable
• Buflomedil hydrochloride
• Controlled-release

Acrylamide grafted copolymer of locust bean gum was prepared by microwave irradiation using ceric ammonium nitrate as redox initiator. The grafting process was optimized in terms of irradiation time, amount of initiator and acrylamide by using constant amount of native locust bean gum. The grafted gum was characterized by Fourier transform infrared spectroscopy (FT-IR), C-13 nuclear magnetic resonance (NMR), scanning electron microscopy (SEM), X-ray diffraction study (XRD), differential scanning calorimetry (DSC), elemental analysis, contact angle, viscosity, molecular weight, swelling and biodegradability studies. The grafted gum was found to be biodegradable and non-toxic. It was further used to prepare controlled-release matrix tablet of buflomedil hydrochloride. The in vitro release profile of the tablet showed the rate controlling property of acrylamide grafted locust bean gum was similar to that of hydroxypropyl methylcellulose (HPMC-K15M).

• 出版日期2013-10-15