Association of high-level humidifier disinfectant exposure with lung injury in preschool children

作者：Park Dong Uk; Ryu Seung Hun; Roh Hyun Suk; Lee Eun; Cho Hyun Ju; Yoon Jisun; Lee So Yeon; Cho Young Ah; Do Kyung Hyun; Hong Soo Jong^*

来源：Science of the Total Environment, 2018, 616: 855-862.

DOI：10.1016/j.scitotenv.2017.10.237

• Exposure to household products
• PHMG
• PGH
• CMIT
• MIT
• Humidifier disinfectants
• Humidifier disinfectant-associated lung injury

Background: Children aged <= 6 years reportedly account for 52% of victims of humidifier disinfectant-associated lung injuries.
Objectives: To evaluate the association of humidifier disinfectants with lung injury risk among children aged <= 6 years.
Methods: Patients with humidifier disinfectant-associated lung injuries (n=214) who were clinically evaluated to have a definite (n=108), probable (n=49), or possible (n=57) association with humidifier disinfectants as well as control patients (n=123) with lung injury deemed unlikely to be associated with humidifier disinfectant use were evaluated to determine factors associated with increased risk of humidifier disinfectant-associated lung injury using unconditional multiple logistic regression analysis.
Results: For estimated airborne humidifier disinfectant concentrations, risk of humidifier disinfectant-associated lung injury increased >= two-fold in a dose-dependent manner in the highest quartile (Q4, 135-1443 mu g/m(3)) compared with that in the lowest quartile (Q1, <= 33 mu g/m(3)). Registered patients using more than two humidifier disinfectant brands were at an increased risk of humidifier disinfectant-associated lung injury (adjusted OR, 2.2; 95% confidence interval, 1.3-3.8) compared with those using only one brand. With respect to the duration of humidifier disinfectant use, risk of humidifier disinfectant-associated lung injury increased >= two-fold in the lowest quartile (<= 5 months) compared with that in the highest quartile ((>=)14 months; adjusted OR 0.3; 95% confidence interval, 0.2-0.6).
Conclusions: Younger children are more vulnerable to HDLI when exposed to HD chemicals within short period in early life.

• 出版日期2018-3