Minimum alveolar concentrations of sevoflurane for maintaining bispectral index below 50 in children

作者：Tsuruta Shouhei; Satsumae Tsuyoshi^*; Mizutani Taro; Inomata Shinichi; Shimizu Takeru; Takahashi Shinji; Tanaka Makoto

来源：Paediatric Anaesthesia, 2011, 21(11): 1124-1127.

DOI：10.1111/j.1460-9592.2011.03602.x

• anesthesia pediatric
• sevoflurane
• endtidal concentration
• bispectral index

Objective: To determine minimum alveolar concentration (MAC) of sevoflurane for maintaining bispectral index (BIS) below 50 (MAC(BIS50)) in children.
Background: MAC(BIS50) of sevoflurane in adults was reported to be 0.97%, which has not been elucidated in children.
Methods/Materials: Twenty children, American Society of Anesthesiologists physical status I or II, aged 1-8, were induced and anesthetized with sevoflurane in oxygen. After tracheal intubation, we started maintenance of anesthesia with endtidal sevoflurane concentrations of 2.6%. The endtidal sevoflurane concentration at which BIS was measured was predetermined by the up-down method (with 0.2% as a step size). After 10 min at predetermined endtidal sevoflurane concentrations, BIS was measured for 1 min. MAC(BIS50) was determined using Dixon's up-down method and probit test.
Result: MAC(BIS50) of sevoflurane was 2.83% (95% confidence intervals: 2.70-3.14) in children.
Conclusions: MAC(BIS50) of sevoflurane in children was calculated to be three times as high as in adults. This indicates that high endtidal sevoflurane concentration is required to suppress electroencephalogram activity in children.

• 出版日期2011-11