A New Polyoxygenated Seco-cyclohexene Derivative from Artabottys pilosus

作者：Liu, Yanping^*; Huang, Ligang; Wang, Xiaocui; Wen, Chenquan; Xu, Shasha; Song, Xiaoping; Han, Changri; Chen, Guangying; Fu, Yanhui

来源：Chinese Journal of Organic Chemistry, 2015, 35(9): 1981-1984.

DOI：10.6023/cjoc201505007

• Artabotrys
• Artabotrys pilosus
• artapilosol A
• cytotoxicity

A new polyoxygenated seco-cyclohexene derivative, artapilosol A (1), together with two known polyoxygenated seco-cyclohexene derivatives, microcarpin A (2) and uvarisubol B (3), was isolated from the stems and leaves of Artabottys pilosus. Their structures were established on the basis of extensive spectral data. This is the first report that polyoxygenated seco-cyclohexene derivatives were isolated from the genus Artabotrys. Cytotoxicities of compounds 1 similar to 3 were tested against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7 and SW480). Results showed that compounds 1 similar to 3 exhibited significant inhibitory effects with IC50 values comparable to those of cisplatin.

• 出版日期2015-9
• 单位海南师范大学