Alkaline earth metal catalyzed cascade, one-pot, solvent-free, and scalable synthesis of pyranocoumarins and benzo[b]pyrans

作者：Yaragorla Srinivasarao^*; Saini Pyare Lal; Singh Garima

来源：Tetrahedron Letters, 2015, 56(13): 1649-1653.

DOI：10.1016/j.tetlet.2015.02.023

• Pyranocoumarins
• Benzopyrans
• Ca(II) catalysis
• Solvent-free synthesis
• Cascade synthesis

Ca(OTf)(2) catalyzed, cascade, one-pot, conjugate addition and annulation of various nucleophiles to the alpha,beta-unsaturated carbonyl compounds for the synthesis of biologically potent pyranocoumarins and benzo[b]pyrans has been illustrated. This one-pot, solvent-free, green-synthesis employs simple reaction conditions, with high yields and endures the substrate diversity.

• 出版日期2015-3-25