Asymmetric synthesis of N-stereogenic molecules: diastereoselective double aza-Michael reaction

作者：Lauber Alex; Zelenay Benjamin; Cvengros Jan^*

来源：Chemical Communications, 2014, 50(10): 1195-1197.

DOI：10.1039/c3cc48486f

A novel approach towards the asymmetric synthesis of N-stereogenic molecules via double aza-Michael addition was developed. The diastereomeric ratio can be increased by a thermodynamically controlled isomerization mechanism. Simple separation and functionalization of the products afford N-stereogenic compounds in high enantiomeric purity.

• 出版日期2014