Development of human striatal anlagen after transplantation in a patient with Huntington's disease

作者：Gallina Pasquale; Paganini Marco; Lombardini Letizia; Saccardi Riccardo; Marini Mirca; De Cristofaro Maria Teresa; Pinzani Pamela; Salvianti Francesca; Crescioli Clara; Di Rita Andrea; Bucciantini Sandra; Mechi Claudia; Sarchielli Erica; Moretti Marco; Piacentini Silvia; Gritti Gaetano; Bosi Alberto; Sorbi Sandro; Orlandini Giovanni; Vannelli Gabriella B^*; Di Lorenzo Nicola

来源：Experimental Neurology, 2008, 213(1): 241-244.

DOI：10.1016/j.expneurol.2008.06.003

• neurotransplantation
• fetal striatal tissue
• Huntington's disease
• neuroblasts
• restoration

Replacement of damaged neuronal Population by fetal tissue transplantation represents a potential treatment for neurodegenerative diseases. Consistent Success has been achieved with fetal striatal transplantation in Huntington's disease animal models and patients. We report the neo-generation of metabolically active tissue with striatum-like imaging features after transplantation of striatal primordia in a patient with Huntington's disease. This Study represents the first "in vivo" demonstration that a human striatal anlagen, transplanted into the adult human brain, is able to progress in its development and to generate a new anatomical structure in the host, without evidence of neoplasia or teratoma.

• 出版日期2008-9